||In this study we synthesized safe and efficient Halloysite-hydrogel nanocomposite for colon cancer drug delivery using biocompatible and biodegradable materials composed from sodium haluronate with poly(hydroxyethyl methacrylate). Further, hydrogel nanocomposites were characterized by various techniques such as fourier transforms infrared spectroscopy, X-ray diffraction technique, thermogravimetric analysis, and scanning electron microscopy technique to confirm the formation, crystallinity, thermal and morphological properties. The hydrogels exhibited good swelling property with pH sensitive fashion. 5-fluorouracil is an anticancer drug was successfully encapsulated into these hydrogels as well as inside halloysite nano tubes via equilibrium swelling followed by pulling and breaking the vacuum. Furthermore the release studies were carried out pH 1.2 followed by 7.4 phosphate buffer media indicates these new type of hydrogels are promising carriers for colon cancer delivery.