화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터)
권호 37권 2호
발표분야 의료용 고분자 부문위원회
제목 Synthesis and characteristics of thermo- and pH-responsive gels based on PEG-b-polyaspartamide by click chemistry
초록 In this work, thermo- and pH-responsive copolymers, methoxy poly(ethylene glycol)-block-polyaspartamides, were prepared from PEG-b-PSI through aminolysis using 2-diisopropylaminoethyl (DIP) and propargylamine (PPGA) as a pH-sensitive and clickable group, respectively. The PEG-b-polyaspartamide was then crosslinked with diazido compounds to afford the corresponding gel by click reaction. The LCST of the block copolymers in an aqueous solution was varied by changing both the graft composition and pH of the medium. The click gels showed stimuli-responsive behavior, in their degree of swelling and structure morphology changing with temperature and pH. These novel stimuli-responsive polymers have potential as smart drug delivery carriers and hydrogel matrices.
저자 김지흥, 문종록, 안소민
소속 성균관대
키워드 gel; stimuli responsive; polyaspartamide; click reaction
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