화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터)
권호 37권 1호
발표분야 고분자합성
제목 Facile Fabrication of Mono-disperse Hollow Spheres by Self-Assembled Organic Molecule and Their Use in Targeted Drug Release
초록 Here we have synthesized complex 5-(bis (4-amino-3, 5-dimethylphenyl) (3, 4, 5-trihydroxyphenyl) methyl) benzene-1, 2, 3-triol (DMHT) consisted of conjugate hydroxyl and amide groups, which facilitate the formation of fascinating self-assembling architecture through intermolecular π-π stacking and hydrogen bonds interaction. We discover the spontaneous formation of nanoscale hollow spheres with highly stable structure and relatively narrow size distribution. This discovery prompts us to develop a direct method for the fabrication of low-molecular mass nanocapsules in template free. Folic acid (FA) and rhodamine 6G (Rh6G) were successfully grafted onto DMHT hollow spheres via amide and hydroxyl reaction. The FA and Rh6G conjugated DMHT hollow spheres (FA-Rh6G-DMHT) could be targeted specifically taken up by CT26 cells via FA receptor-mediated endocytosis. Doxorubicin hydrochloride (DOX), an anticancer drug, was introduced into FA-Rh6G-DMHT hollow spheres.
저자 황신화1, 장리동2, 김일1
소속 1부산대, 2합성고분자생물접합하이브리드재료사업단
키워드 Hollow spheres; Folic acid; Rhodamine 6G; Self-assembly; Targeted drug delivery
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