화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터)
권호 36권 2호
발표분야 대학원생 구두발표
제목 Fully Biodegradable and Biocompatible polymeric prodrug nanoparticles with antioxidant, anti-inflammatory and anti-apoptotic Activities
초록 Reactive oxygen species (ROS) induce the oxidative stress, programmed cell death and the expression of many cytokines. p-Hydroxybenzyl alcohol (HBA) is known to play a pivotal protective role against inflammatory and oxidative stress-related diseases. We have developed a new biodegradable multifunctional peroxalate copolymer containg HBA (HPOX). Peroxalate ester linkages in the backbone reacted with and scavenged hydrogen peroxide, leading the release of HBA. We found that HPOX nanoparticles exerted stronger antioxidant, anti-inflammatory and anti-apoptotic activities than free HBA in antioxidant activities. HPOX nanoparticles effectively reduced generation of nitric oxide, tumor necrosis factor-alpha (TNF-a) and suppressed apoptisis of stimulated RAW 264.7 cells. Therefore, we suggest that HPOX nanoparticles are highly potent for the treatment of oxidative damage-related diseases.
저자 조수진, 김하늘, 국경혜, 박승규, 이동원
소속 전북대
키워드 Produg; anti-inflammation; anti-apotosis
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