화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터)
권호 35권 1호
발표분야 의료용 고분자 부문위원회
제목 Fabrication of Biodegradable Porous Microspheres with BMP-2 Releasing Nano-Hydroxyapatite for Bone Regeneration
초록 The systematic combination of biodegradable polymers, calcium phosphates (CaP), and BMP-2 is recognized as a useful approach to produce high-performance bone-regenerative scaffolds. Herein, we report on porous poly(lactide-co-glycolide) (PLGA) microspheres with surface-immobilized n-HAp that can release BMP-2 in a controlled manner. For enhancing bone regeneration, surface-immobilized n-HAp and BMP-2 are expected to exhibits each inherent function: N-HAp may contribute to the initial cell attachment and proliferation by offering the cell-friendly environments. In addition, the released BMP-2 can induce the stem cell differentiation to osteoblasts, and the prolonged release induces the mature bone formation. In this work, we demonstrated the synergistic effect of BMP-2 with surface-immobilized n-HAp on in vitro osteogenic potentials.
저자 전병진, 구안나, 정서영, 이상천
소속 경희대
키워드 microspheres; tissue engineering; growth factors
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