화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터)
권호 35권 1호
발표분야 고분자 합성
제목 Dendritic Poly(ethylene glycol) by Aninoic Ring Opening Polymerization
초록 Anti-fouling materials are important to prevent the absorption of non-specific proteins at the surface of for implanted biomaterials and biosensors. Poly(ethylene glycols)(PEG) is a representative anti-fouling materials. Peglyated protein is an example of application PEG to drug delivery systems. To improve anti-fouling effect of PEG, dendritic poly(ethylene oxide)s were synthesized by iterative divergent methods based on anionic ring-opening polymerization of ethylene oxide. Here, we describe the dendron type PEOs up to generation number 3 with 8 peripheral hydroxyl functions and one focal function with cyclic acetal for PEGylation. We employed an initiating system composed of amine an initiator and DPMK as electron transfer agents in THF. Allyl bromide was introduced to branching polymeric chain ends for end functionality. All generations are characterized by 1H NMR spectroscopy, GPC and MALDI-TOF.
저자 허정윤1, 안철희1, 김정안2
소속 1서울대, 2경희대
키워드 poly(ethylene glycols); anioic polymerization; dendrimer
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