화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터)
권호 35권 1호
발표분야 의료용 고분자 부문위원회
제목 Nanohealing using dual growth factor delivery with self-assembling peptide nanofiber hydrogel and in myocardial infarction in vivo
초록 Here we demonstrate that myocardial protection of infracted heart using dual growth factor delivery with self-assembling peptide nanofiber hydrogel (SAP), RADAII-16. Myoardial infarction (MI) was produced in ~ 150g SD rat. After left coronary artery ligation, growth factor with SAPNS was injected into infracted border zone (n=6 in each group: Sham, MI, MI + SAP, MI + SAP/FGF-2, MI + SAP/PDGF-BB, MI + SAP/FGF-2/PDGF-BB, and FGF-2/PDGF-BB). The hearts were harvested 4 weeks after for functional and histological analysis. Infarct area was 22.3 ± 3.6 % in MI + SAP/FGF-2, 17.3 ± 0.7 % in MI + SAP/PDGF-BB, and 8.5 ± 2.2 % in MI + SAP/FGF-2/PDGF-BB. Ejection fraction was 30.7 ± 0.6 %, 34.1 ± 0.8 %, and 43.7 ± 1.4 % in each group (compared to 18.37 ± 2.9 % in MI, 51.0 ±1.8 in sham). In this study, dual growth factor delivery with SAP is effective to myocardial protection and leads to improvement in cardiac function.
저자 김지현1, 박용두2, 윤소정2, 정영미1, 김상헌1, 선경2, 김희찬3, 김수현1
소속 1한국과학기술(연), 2고려대, 3서울대
키워드 dual growth factor; self-assembling peptide nanofibers; myocardial infarction
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