화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관)
권호 34권 2호
발표분야 의료용 고분자 부문위원회
제목 Preparation of reduction sensitive self-aggregates for drug delivery
초록 Amphiphilic block copolymers assemble into nanoscopic core-shell structures, self-aggregates, which are of considerable interest for the delivery of hydrophobic anticancer drug. In this study focused on achieving prolonged circulation times for passive targeting of chemotherapeutic agents and environment sensitivity of the self-aggregates. We designed polymeric aggregates with Poly(ethylene glycol) and Poly(ε-caprolactone) based copolymer containing functional groups between two block segments for drug delivery. Poly(ethylene glycol) are sterically stabilized and undergo less opsonization and uptake by the macrophages of the reticuloendothelial system (RES), allowing the aggregate to circulate longer in blood. Semi-crystalline part of Poly(ε-caprolactone) block is biodegradable and resorbable in a suitable period of time. Functional groups are thiol residues which form disulfide bond that lead to reduction-sensitive release of anticancer drug.
저자 김주은, 안철희
소속 서울대
키워드 self-aggregates; reduction sensitive; drug delivery
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