화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔)
권호 13권 1호, p.9
발표분야 고분자
제목 Morphology controls of self-assembled nanoparticles by the secondary structures of poly(amino acid)s
초록 PHEA containing amine group in the side chain was synthesized by aminolysis of PSI with 2-aminoethanol and 1,6-hexanediamine. PHEA-g-oligo(L-lysine) was successfully synthesized using living polymerization of α-amino acid-N-carboxyanhydrides. Self-assembled nanoparticles of PHEA-g-oligo(L-lysine) in an aqueous solution was fabricated. The morphology changes of self-assembled nanoparticles were induced by the pH or temperature-responsive conformational transition of specific poly (amino acid) group. The conformational transition of secondary structure of poly (amino acid) group was confirmed by CD (circular dichroism). The morphology of self-assembled nanoparticles are studied by TEM and DLS.
The surface plasmon resonance (SPR) biosensor has been widely used to investigate binding event occurring on biological surfaces by the detection of a refractive index change on a gold surface without the need to label molecules. We also, through the SPR study, verify physicochemical properties of conformational transition of poly (amino acid).
저자 한고운, 정재현, 이현진, 김종득
소속 한국과학기술원
키워드 poly(amino acid); SPR; secondary structure
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