화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터)
권호 46권 2호
발표분야 의료용 고분자 부문위원회 Ⅰ,Ⅱ
제목 Dual Padlock GLP1 Gene Delivery System to Treat Type 2 Diabetes Mellitus: One-week Glucose Level Control with a Single Dose
초록 We investigated the effect of dose quantity on the therapeutic efficacy of oral GLP1 gene therapy. Using a multimodal gene complex (GLP1/PTCA), we showed glycemic improvement drawn for up to 1 week in three progressives diabetic mouse models. To the best of our knowledge, this is the first report of any dosage form of GLP1 agonist for the most extended period of glucose control using a minimal quantity of genes (<0.5 mg human equivalent dose). Since Rybelsus® is the only FDA-approved oral GLP1 agonist that needs to be taken with 7 or 14 mg daily, oral GLP1/PTCA may provide the first once or bi-monthly oral treatment option for diabetic patients according to allometric principles.
저자 안정만1, 이동윤1, 이용규2
소속 1한양대, 2한국교통대
키워드 diabetes; biotechnology; Drug and gene delivery
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