||We have investigated the change of tensile strength (TS) of Natural rubber/chloroprene rubber (NR/CR) blends during combination ageing, including heating and dynamic mechanical loading. Using model of statistical experiment, we built the equation describing the dependence of TS on four factors: temperature T, number of cyclic loadings N, contents of NR (CNR) and chloroprene (CCR). This equation allows predict the TS change of NR/CR blends after combination ageing with accepted inaccuracy – less than 10%. We also investigated the effect of nanofillers, such as nanoclay, SiO2, Fe3O4, on adhesion of some rubber blends to polyester and steel cords. It was found, in the case of EPDM/CIIR rubber blends, both nanoclay and SiO2 have no effect on adhesion to steel cords, while nano SiO2 may enhance adhesion to polyester cords. On other side, Fe3O4 may remarkably enhance adhesion of NR/CR blends to steel. Mentioned results are successfully applied in some practical rubber products working under fatigue conditions, such as rubber/steel antivibration pad for locomotive, heat resistant conveyor, water dam, underwater lift bag.