화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center))
권호 24권 1호
발표분야 학생우수논문발표(박사과정)
제목 2D transition metal dichalcogenide nanomedicines for sepsis treatment
초록 It is of great significance to reduce the imflammation caused by reactive oxygen species (ROS) for sepsis treatment. Herein, biocompatible transition metal dichalcogenide (TMD) nanosheets were exploited as stable and powerful antioxidants for sepsis treatment. To this end, TMD nanosheets were exfoliated and functionalized by an amphiphilic polymer in an aqueous solution. The exfoliated TMD nanosheets showed unique cellular scavenging activities for various types of ROS and nitric oxide (NO) in BMDMs stimulated by lipopolysaccharide. It was found that WS2 nanosheets exhibited the highest activity for reduction of inflammatory factors in the living cells via intracellular ROS scavenging. In addition, WS2 nanosheets showed the excellent performance in sepsis-induced mouse models, leading to an increase in their survival rate.  
저자 임다빈, 김종호
소속 한양대
키워드 Transition Metal Dichalcogenides (TMDs); antioxidant; radical scavenging; anti-inflammation; sepsis
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