||The hydrophilic acrylic PSAs were synthesized by controlling the contents of 2-ethylhexyl acrylate, isobornyl acrylate, and 2-hydroxyethyl acrylate. Surface contact angle of acrylic PSA film decreased from 77.87˚ to 70.23˚ in case of Acryl-2 to Acryl-8 (below HEA 10 wt%). However, the surface contact angle of Acryl-10 to Acryl-40 (HEA 10 wt% to 40 wt%) increased up to 92.29˚, indicating hydrophobicity. According to X-ray diffraction measurement, hydrophilic acrylic PSAs exhibits amorphous property and it was confirmed that the morphology of acrylic PSA film was significantly affected by the flexibility of the polymer chain and the strength of hydrogen bonding. The affinity with hydrophilic materials for acrylic PSA films is determined by the hydrophilicity of the acrylic PSA film. Synthesized acrylic PSA film is non-toxic regardless of the hydrophilicity, any irritation was not observed in the skin where the acrylic PSA film was attached even after 72 hr.