화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center))
권호 24권 1호
발표분야 포스터-정밀화학
제목 A Medical Patch for Chronic Wound to Quantify MMP-9 Concentration
초록 Due to the aging of the population, patients with cerebrovascular disease or diabetes and chronic wounds, including complications of ulcers and diabetic foot ulcers, are increasing rapidly. For this reason, there have been many studies to develop wound sensors based on various targets. MMP-9 is considered as a major marker because it is over-expressed when wounds are exacerbated. Previous studies have confirmed that fluorescence increases with the quantity of MMP-9 of hydrogel. In this study, we have developed a technique for immobilizing a FRET-peptide of hydrogel on PDMS supports to quantify MMP-9 concentration in a certain solution. When the fluorescent peptide that is cleaved by a specific protease, the amount of MMP-9 can be measured by the fluorescence increase of the hydrogel. This hydrogel-based biosensor could be an important tool for improving as patch type wound dressing or flexible device in the medical filed.
저자 조하나1, 강소민2, 허찬영3, 신동식1
소속 1숙명여자대, 2분당서울대, 3서울대
키워드 Hydrogel; PDMS; Protease; MMP-9; Fluorescence
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