화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO))
권호 45권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Development of pH-responsive polymeric nanocarrier for delivery of methotrexate to rheumatoid arthritis
초록 In this study, we developed hyaluronic acid (HA) and 5β-cholanic acid-based nanocarriers (HA-NCs) loaded with methotrexate (MTX) for the treatment of rheumatoid arthritis (RA). The HA-NCs are composed of HA for targeting the CD44-overexpressed inflamed synovial environment. Furthermore, HA-NCs have ketal linkage which can be broken down in response to mildly acidic conditions of RA. In in vitro study, we confirmed the MTX released from MTX-HA-NCs when exposed to acidic conditions. Also, MTX-free HA-NCs did not have cytotoxicity to RAW 264.7 cell. In in vivo biodistribution, when Cy5.5-labeled HA-NCs was systemically administered to collagen-induced arthritis mice, the HA-NCs were accumulated in RA lesion by receptor-mediated endocytosis. This biocompatible polymeric NCs have potential as a drug carrier that selectively releases MTX to diseased sites by pH-responsiveness.
저자 윤빈, 전주은, 박재형
소속 성균관대
키워드 Nanocarrier; pH-responsive; Rheumatoid arthritis
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