화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO))
권호 45권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Biodegradable Polymer-based Radiopaque Micropaticles for Transarterial Chemoembolization
초록 Transarterial Embolization (TAE) is one of the therapeutic methods for hepatocellular carcinoma (HCC), blocking blood vessel in tumor with embolic materials. Conventional embolic beads, however, are usually non-biodegradable and have no x-ray visibility, which cause risk of medical malpractice and difficulty in repetitive injection. Therefore, it is essential to develop advanced embolic bead with biodegradability and radiopacity itself. In this research, well-calibrated microparticles (MPs) were formed. Diameter and size distribution of the final product were analyzed with optical microscope. The x-ray visibility was determined with real-time C-arm device. The diameter of MPs was about several hundred micrometers, and it showed narrow size distribution. MPs were determined to have enough x-ray attenuation property to be visualized with C-arm device. In conclusion, we confirmed the potential of these biodegradable polymeric MPs to be applied to cancer therapy.
저자 전성익1, 제환준2, 안철희3
소속 1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering
키워드 Transarterial embolization; embolic material; microsphere; biodegradable polymer
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