화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO))
권호 45권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Supramolecular Injectable Hyaluronate Hydrogels for Cartilage Tissue Regeneration
초록 Mesenchymal stem cells (MSCs) have been widely investigated to repair damaged cartilage tissues for the treatment of arthritis. Despite these great efforts, the difficulty in the spatiotemporal control of delivered cells has limited the further clinical development with rapid clearance. Here, we developed injectable hyaluronate (HA) hydrogels to encapsulate MSCs for controlled cartilage tissue regeneration based on the supramolecular chemistry between β-cyclodextrin (β-CD) modified HA (HA-CD) and adamantane (Ad) modified HA (HA-Ad). The spatiotemporally controlled delivery of MSCs from the supramolecular HA hydrogels resulted in the statistically significant chondrogenic differentiation and extracellular matrix (ECM) deposition in vitro and in vivo. Taken together, supramolecular HA hydrogels might be successfully harnessed as an injectable delivery system of MSCs for cartilage tissue regeneration and other tissue engineering applications.
저자 정상훈, 한세광
소속 포항공과대
키워드 Mesenchymal stem cell; hyaluronate; supramolecular hydrogel; cell therapy; cartilage tissue regeneration
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