화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO))
권호 45권 1호
발표분야 기능성 고분자
제목 NIR-triggered photodynamic therapy and bioimaging based on multi-shell structured upconversion nanoparticles
초록 Lanthanide-doped upconversion nanoparticles (UCNPs), which can emit high energy visible light upon near-infrared (NIR) excitation, have been intensively employed for biomedical field due to high photostability, deep penetration into tissues, low toxicity, and significantly improved signal-to-noise ratio in optical bioimaging. In general, since green emissions emitted from UCNP is greater than red emissions, photodynamic therapy (PDT) using photosensitizer (PS) activated for red emissions has little effect. In this study, a multi-shell structured UCNPs, which have enhanced photoluminescence and can emit UV, blue, green and red emission, were fabricated. Then, their surface modification was conducted for NIR-triggered PDT and bioimaging. In addition, the morphology and photoluminescence effect of multi-shell structured UCNPs were investigated.
저자 최종선, 김소연
소속 충남대
키워드 upconversion nanoparticle; photodynamic therapy; bioimaging; near-infrared
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