화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO))
권호 45권 1호
발표분야 대학원생 구두발표 (영어발표, 발표15분)
제목 Injectable Hydrogels Scavenging Reactive Oxygen Species for Wound Management and Tissue Repair
초록 Injectable hydrogels have been widely used as wound dressing because they can maintain a moist wound microenvironmet that protect the wound from bacterial infection and absorb large amount of exudates. However, the excessive reactive oxygen species (ROS) at the injured sites can impair cutaneous wound healing by triggering deleterious processes (e.g., necrosis, inflammation and fibrotic scarring). Herein, we developed an injectable hydrogel with highly free radical scavenging properties, using the antioxidant gallic acid conjugated gelatin (GGA). The hydrogels were rapidly formed within 10 sec via HRP-catalyzed cross-linking reaction. The physico-chemical properties and free radical scavenging activities of hydrogels were characterized and controlled. The effect of hydrogels on promoting the wound healing and repair was also investigated in vivo, using a full-thickness mice skin defect model. Acknowledgement: NRF-2018R1A2B2004529 & 2019R1A6A1A11051471
저자 Phuong Le Thi, 박기동
소속 아주대
키워드 Hydrogel; ROS; Wound repair; Gallic acid
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