화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU))
권호 23권 2호
발표분야 포스터_생체재료
제목 Cancer treatment using drug loaded pH-responsive C-Dots
초록 pH-responsive polymers are used for various application such as drug delivery, gene delivery, etc. But, pH-responsive polymers have several disadvantages such as unavoidable synthesis, wide distribution of molecular weight, unregulatable drug loading and release rate, toxicity and biodegradation. So, we developed pH-responsive carbon dots(C-Dots). C-Dots are made through organic materials containing carbon, and various methods such as hydrothermal, microwave, pyrolysis, etc. We synthesized drug loaded pH-responsive C-Dots (pRC-Dots) through microwave method. Drug release rate in pRC-Dots are higher than in control group at tumor environment mimic pH. In vitro test, we confirmed the therapeutic effect using human colon cancer, human pancreatic cancer, and human breast cancer cell lines. Also, we confirmed the pRC-Dots therapeutic effect by in vivo test using tumor bearing mouse. As a result, we show that pRC-Dots have the possibility to be used as a tumor treating material.
저자 이장수, 서정덕, 이종환, 이채빈, 배수경, 나건
소속 가톨릭대
키워드 carbon dot; cancer therapy
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