화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU))
권호 23권 2호
발표분야 (콜로이드·계면화학) 무기물 기반 콜로이드 물질의 제조와 응용
제목 2D Transition Metal Dichalcogenide Antioxidants for Prolonged ROS Scavenging
초록 Owing to the physiological and pathophysiological roles of reactive oxygen species (ROS), there is an increasing demand to regulate the concentration of ROS in biological processes. Herein, we present a novel approach for the exfoliation and functionalization of transition metal dichalcogenides (TMDs) in water via modulation of the hydrophobic interaction between poly(ε-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) and the basal planes of TMDs. Decreasing the hydrophobic PCL length of PCL-b-PEG significantly increases the exfoliation efficiency of TMD nanosheets because of the increased polymer–TMD hydrophobic interaction. The TMD nanosheets exfoliated by PCL460-b-PEG5000 show excellent and prolonged scavenging activity for ROS, but each type of TMD displays a different scavenging tendency against hydroxyl and superoxide radicals. As-prepared 460-TMDs are able to effectively scavenge ROS in HaCaT human keratinocytes, and also exhibit excellent biocompatibility.
저자 김종호
소속 한양대
키워드 antioxidant; liquid-phase exfoliation; transition metal dichalcogenide; ROS scavenging
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