화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 의료용 고분자 부문위원회 II
제목 The remodeling effect of Heparin/Substance P conjugated PLCL polymer coating on bioinert ePTFE
초록 ePTFE vascular grafts have been mainly used to treat vascular disease in clinics. However, in small diameter vascular grafts (<6mm), restenosis may occur after bypass surgery and poor long-term patency lead to implant failure. Thus, surface modification is necessary to remodel artificial vascular grafts into bioactive vascular grafts that can recruit vascular cells (ECs, SMCs). Heparin, which inhibits thrombosis, or Substance P, which recruits stem cells and vascular cells, were covalently conjugated with Poly(l-lactide-co-ε-caprolactone) and then, they were coated into the ePTFE. Hep-PLCL and/or SP-PLCL coated ePTFE grafts (Hep-PLCL and SP-PLCL and Hep/SP-PLCL) were implanted subcutaneously and it was assessed whether the coating induces remodeling into bioactive vascular grafts like native vessels.
저자 김동학1, 정영미2, 김수현2
소속 1고려대, 2한국과학기술(연)
키워드 Heparin; Substance P; artificial grafts; coating
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