||ePTFE vascular grafts have been mainly used to treat vascular disease in clinics. However, in small diameter vascular grafts (＜6mm), restenosis may occur after bypass surgery and poor long-term patency lead to implant failure. Thus, surface modification is necessary to remodel artificial vascular grafts into bioactive vascular grafts that can recruit vascular cells (ECs, SMCs). Heparin, which inhibits thrombosis, or Substance P, which recruits stem cells and vascular cells, were covalently conjugated with Poly(l-lactide-co-ε-caprolactone) and then, they were coated into the ePTFE. Hep-PLCL and/or SP-PLCL coated ePTFE grafts (Hep-PLCL and SP-PLCL and Hep/SP-PLCL) were implanted subcutaneously and it was assessed whether the coating induces remodeling into bioactive vascular grafts like native vessels.