||Bone is one of the most transplanted tissues, but there are no materials that can fulfill all the requirements for bone substitution. Bioactive glasses are known for accelerating bone regeneration. However, their brittle mechanical properties make them unsuitable for repairing defect sites that are exposed to cyclic loading. Silica-polymer hybrids are one-phased materials that have inter-penetrating network via covalent bonds. The combination of silica and polymer not only allows possibilities to design flexible bioactive glasses, but also for fabricating homogenous materials. Poly(urethane)(PU), which is used for blood contacting medical devices due to their durability and elasticity, was co-polymerized with polycaprolactone-diol as a biodegradable soft segment, and (3-Aminopropyl)triethoxysilane as a coupling agent. The PU was then introduced to silica network via sol-gel process. The tough and biodegradable silica-PU hybrid is a promising biomaterial for bone regenerating scaffolds.