||Natural polymers with biocompatibility and biodegradability have been utilized for dermal fillers. However, the rapid degradation of natural polymers has the disadvantage of lowering persistence in vivo. Recently, many attempts have been made to overcome the limitations by using synthetic polymers. Although the synthetic polymers such as polyesters have long-term stability compared to the natural polymers, acidic byproducts from the polyesters cause inflammation. Here, multifunctional polymeric microspheres were prepared with ceramic nanoparticles via the membrane emulsification method. In in vitro, the ceramic nanoparticles incorporated polymeric microspheres significantly reduced inflammation due to neutralization effect. Also, the multifunctional polymeric microsphere reduced collagen degradation with inhibited cellular senescence. The multifunctional polymeric microspheres are expected to be applicable as a new type of dermal filler in a wide range of medical devices.