화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 고분자합성
제목 Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing
초록 We developed a bioinspired pH- and temperature-responsive in situ-forming injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications. The pH- and temperature-responsive copolymer, composed of hydrophilic poly(ethylene glycol) (PEG) and pH- and temperature-responsive poly(sulfamethazine ester urethane) (PSMEU), has been synthesized as in situ-forming injectable hydrogel. PEG-PSMEU copolymers exist as low viscous sols at high pH and room temperature (pH 8.5, 23 oC); whereas, they transform to a viscoelastic gel at the physiological condition (pH 7.4, 37 oC). Owing to the presence of urethane linkages, the PEG-PSMEU possesses excellent adhesion strength to wide range of surfaces including glass, plastic and fresh organs. The bioinspired pH- and temperature-responsive in situ-forming injectable hydrogel may be promising for biomedical applications such as controlled delivery vehicle, tissue adhesive and tissue regeneration.
저자 Thai Minh Duy Le, Huu Thuy Trang Duong, Thavasyappan Thambi, V. H. Giang Phan, 정지훈, 이두성
소속 Sungkyunkwan Univ.
키워드 Injectable hydrogel; polyplex; urethane ester; DNA; tough adhesive and wound
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