화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 고분자합성
제목 Synthesis of zwitterion functionalized silica nanoparticle with controlled release of nitric oxide for superior antibacterial properties
초록 Zwitterion, which have both positive and negative charge groups, can form hydration layer within the water solution by adjusting pH. If zwitterion is formed on particle surfaces, the foreign body recognition system can be prevented with the same effect as PEGylation, thus can play a role as a biocompatible drug carrier. Therefore, we functionalized silica nanoparticle (SiNP) with amine group by using (3-Aminopropyl)triethoxysiliane (APTES). Then 1,3-Propanesultone (PS) was used to form sulfobetaine zwitterion on amine functionalized SiNP surfaces. Formation of sulfobetaine group was verified by using raman spectroscopy, and the proper pH of the synthesized Zwitterion NP (ZwitNP) was verified with QCM. As a drug carrier, ZwitNP contains secondary amine group in the structure, so ZwitNP can load and release nitric oxide (NO) which is gas molecule drug. Furthermore, it was also confirmed that by adjusting pH of NO-loaded ZwitNP solution, controlling the release rate of NO is possible.
저자 정성원, 홍진기
소속 연세대
키워드 Zwitterion; Silica nanoparticle; controlled release; nitric oxide
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