화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2005년 가을 (10/21 ~ 10/22, 인하대학교)
권호 11권 2호, p.1583
발표분야 제2회 약물전달 기술 심포지엄
제목 Ceramic Hybrid Drug Delivery System for Hard Tissue Therapy
초록 This work demonstrated the highly controlled drug release and its controlled burst release at initial release time for a long period of time with HA nanocomposites of silicified L3-PNIPAm gels for hard tissue therapy, in which the silicified L3 phase and its PNIPAm composite showed the 3-D disordered non-linear porous channels. The aim of this work is to explore a new potential property of capability of acting as a convenient reservoir for long-term controlled drug release for hard tissue. For this purpose, we introduced indomethacin (IMC) into the L3-PNIPAm gels integrated HA scaffold and subsequently demonstrated the in vitro drug release process by the step-wised temperature change. The silicified L3-PNIPAm/HA composites have been prepared, which allows the control of the burst release at the initial time with step-wised temperature. In vitro analysis carried out with prepared material showed the non-cytotoxic, and well growing on surface of the matrix.
저자 장정호
소속 한국요업(세라믹)기술원
키워드 hydroxyapatite; nanoporous; cytotoxicity
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