화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 대학원생 구두발표 (발표15분)
제목 Robust nanoplatform with protein corona shield system for highly efficient targeted drug delivery
초록 Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents. However, translating nanoparticle-based agents into clinical applications still remains a challenge due to the difficulty in regulating interactions on the interfaces between nanoparticles and biological systems. Here, we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein combines with glutathione-S-transferase. Once thermodynamically stabilized in preferred orientations on the nanoparticles, the adsorbed fusion proteins as a corona minimize interactions with serum proteins to prevent the clearance of nanoparticles by macrophages, while ensuring systematic targeting functions in vitro and in vivo. This study provides insight into the use of the supramolecularly built protein corona shield as a targeting agent through regulating the interfaces between nanoparticles and biological systems.
저자 오준용, 유자형
소속 울산과학기술원
키워드 protein corona; silica nanoparticle; fusion protein; target drug delivery;
E-Mail