화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 Korea-Australia Joint Symposium: Next Generation Polymer Science and Technology (English)
제목 Synthesis of Gradient Copolymers Based on One-pot Cationic Copolymerization of Aliphatic and Aromatic 2-Oxazolines
초록 Gradient amphiphilic copolymers represent unique class of copolymers with the gradual monomers composition distribution along the polymer chain adopting similar self-assembly behavior as in the case of amphiphilic block copolymers. Poly(2-oxazolines) prepared via living cationic ring-opening polymerization (LCROP) have been recognized as promising biomaterials for different biomedical applications. Recently, gradient copolymers by LCROP of 2-ethyl-2-oxazoline and 2-(4-dodecyloxyphenyl)-2-oxazoline was used for the preparation of highly stable nanoparticle for encapsulation of curcumin. In this work, we present the synthesis of library of gradient copoly(2-oxazolines) with different aromatic 2-oxazolines and different copolymer composition. We investigated the effect of structure of hydrophobic monomer on the self-assembly behavior and drug-loading capacity of selected drugs. Acknowledgment: Authors are thankful SRDA for financial support in the projects SK-KR-18-0011 and APVV-15-0485.
저자 Juraj Kronek1, Jiwon Jeong2, Zuzana Kroneková3, Shubhashis Datta1, Daniel Jancura4, Daewon Sohn5
소속 1Polymer Institute of the Slovak Academy of Sciences, 2Department of Chemistry, 3Hangyang Univ., 4Center for Interdisciplinary Biosciences, 5Technology and Innovation Park
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