화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터)
권호 25권 2호, p.1278
발표분야 공업화학 (Industrial Chemistry)
제목 Physiological Activity of Robinia pseudo acacia Leaf Extracts and Enhancement of Skin Permeation Using Polymer Micelles and Cell Penetrating Peptide
초록 This study was conducted to evaluate physiological activity of Robinia pseudo-acacia leaf and its skin penetration using polymer micelles and skin penetrating peptide. DPPH radical scavenging ability, Elastase inhibitory assay, SOD-like activity, and Tyrosinase inhibitory activity except total polyphenol content showed that Robinia pseudo-acacia leaf ethanol extract was higher than that of the Robinia pseudo acacia leaf hydrothermal extract at all concentrations. In the antimicrobial experiments, the hydrothermal extract had no effect, but ethanol extract represented clear zone in Propionbacterium acnes strain and Bacillus subtilis strain. To solve the problem of insolubility and to improve skin penetration, PCL-PEG polymer micelles containing Robinia pseudo-acacia leaf ethanol extracts and 1% cell permeable peptide, hexa-D-arginine (R6) were successfully prepared with particle size of 108.23 and 126.47 nm and excellent skin permeation effects could be showed.
저자 허수현, 박수인, 안규민, 김민기, 신문삼
소속 을지대
키워드 화장품
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