화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO))
권호 23권 1호
발표분야 디스플레이_포스터
제목 Targeted drug delivery to cancer cell of folic acid-based CQDs synthesized through microwave treatment
초록 Carbon quantum dots (CQDs) have received considerable attentions because of their remarkable optoelectrical properties, excellent biocompatibility, good dispersion stability in aqueous media and non-toxicity to human bodies compared with other semiconductor or inorganic quantum dots (QDs). Folic acid (FA) is targeting materials for drug delivery system because it binds with Folate receptors (FRs) on the surface of cancer cells. In this study, highly fluorescent and multi-functional CQDs have been synthesized from folic acid as a kind of A2B type polyamidation monomer (A:-COOH, B:-NH2) via simple microwave treatment. Synthesized folic acid-based CQDs (FA-CQDs) show strong blue emission, low cytotoxicity by MTT assay, and high cellular uptake by flow cytometer analysis. Consequently, FA-CQDs can be successfully used as targeted drug delivery system for the therapy and diagnosis of cancers. 2019년 한국교통대학교 지원을 받아 수행하였음.
저자 권빈희, 인인식
소속 한국교통대
키워드 Carbon quantum dots; Folic acid; targeted drug delivery
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