화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO))
권호 23권 1호
발표분야 정밀화학_포스터
제목 Microfluidic Generation of Metacrylated Hyaluronic Acid Hydrogel Droplets for Controlling Mechanical Properties in Mild Condition
초록 Recently, there are now widespread examples of modified HA macromers that form either covalent or physical hydrogels through crosslinking reactions such as click chemistry or supramolecular assemblies of guest-host pairs. Here, we engineered methacrylated hyaluronic acid (meHA) with peptide crosslinker to generate bio-orthogonal polymerization. Peptide cross linker is used to trigger degradation by various specific proteases. This study focuses on the microfluidic preparation of monodispersed meHA hydrogel, for which a controllable polymerization technique is proposed. The resulting hydrogel beads can be used for the culture of cells in vitro, as carriers for cells in vivo, or to deliver therapeutics in an environmentally responsive manner.
저자 김성수1, 박경은2, 신동식2
소속 1강원대, 2숙명여자대
키워드 Microfluidic chip; Droplet; Hydrogel; PEG; Hyaluronic Acid
E-Mail