화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO))
권호 23권 1호
발표분야 생체재료_포스터
제목 Temperature modulated injectable hydrogels for long-term delivery of musculoskeletal
초록 Non-steroidal anti-inflammatory drug was known as a various musculoskeletal, however, these drugs have many side effects, such as gastrointestinal ulceration, and renal disorder. To overcome side effects, there have been efforts by directly injecting drug delivery formulation. Several polysaccharides are soft, biocompatible, and biodegradable so that those are directly infused into damage site without invasive surgery. Thermo-sensitive polymers rapidly form hydrogel at a specific temperature, but, this hydrogels formulation is not maintained for long-term in normal condition. Thus, anti-inflammatory drug can be loaded and sustained release. Using these properties, we designed a novel thermal sensitive injectable non-steroidal anti-inflammatory drug formulation simply mixing poly-saccharides and thermo sensitive polymer.
저자 이상희1, 박우람2, 나건1
소속 1가톨릭대, 2차의과학대
키워드 therosensitive micelle; musculoskeletal; anti-inflammatory; injectable hydrogel
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