화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO))
권호 23권 1호
발표분야 생체재료_포스터
제목 Understanding of Melanin Formation Using Polydopamine Coating
초록 In biology, the assemblies of molecules are essential for biological functions. However, biopigment (i.e., melanin) assembly is an unpredictable process because heterogeneous derivatives are consequently produced via the catecholamine oxidation. In this study, we demonstrated that the cation-pi interaction is mainly contributed to the progressive assembly of melanin by changing the species of cations (e.g. R-NH3+, Na+, K+, and NR4+), which can affect the formation of artificial melanin called polydopamine. Through the oxidation process, the artificial melanin includes both electron-rich building blocks with dihydroxyindole groups and cationic building blocks with protonated amine groups. The deprotonation of amine groups causes the disassembly of melanin in the strong alkaline condition. However, the addition of other cations (K+ and NR4+) triggers the re-assembly of melanin in the same strong alkaline condition.
저자 왕윤선, 이해신
소속 한국과학기술원
키워드 cation-pi interaction; melanin; catecholamine; dopamine
E-Mail