화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터)
권호 43권 2호
발표분야 기능성 고분자
제목 Injectable Hydrogel Poly(styrene-alt-maleic anhydride)-Based for Controlled Drug Delivery
초록 A novel new fast gelling hydrogel composed of copolymer Poly(styrene-alt-maleic anhydride) (PSMA) and poly(ethylene glycol) (PEG) with Inverse Electron Demand Deis-Alder (IEDDA) click reaction between tetrazines and norbornenes. The PSMA were subsequently functionalized with 3-(p-benzylamino)-1.2.4.5-tetrazine. The tetrazine groups, were reacted with dinorbonene chain-end functional polyethylene glycol as a cross-linking agent with IEDDA click reaction to produce a hydrogel. All the precursor materials were characterized by FT-IR, GPC, and 1H-NMR. The resulting hydrogel formation within several minutes and the storage modulus (G’) value of hydrogels was in range 0.3-1.7 kPa. The precursors exhibited practically no depressing effect on the normal HEK293 cell growth while the DOX·HCl-loaded hydrogel presented significant anticancer activity towards HeLa cells, which makes this biocompatible hydrogel potential for controlled drug release.
저자 임권택, Daru Seto Bagus Anugrah, K. Ramesh, 박찬, 최원태
소속 부경대
키워드 Injectable Hydrogel; Poly(styrene-alt-maleic anhydride); Click Reaction
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