||Vascular disease have still threaten human life until now. To overcome it, ePTFE vascular grafts have been mainly used in clinics. However, in ePTFE vascular grafts, poor long-term patency and restenosis may occur after bypass surgery and usually lead to implant failure. Thus, remodeling of artificial vascular grafts by recruitment of vascular cells is necessary through surface modification. Heparin and substance P were covalently conjugated with Poly(l-lactide-co-ε-caprolactone) (Hep-PLCL and SP-PLCL) and they were coated on the ePTFE surface. We conducted in vivo test to investigate whether polymer coating induces remodeling of artificial vascular grafts.