화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO))
권호 44권 1호
발표분야 고분자가공/복합재료
제목 Phosphorylcholine surface modified mesoporous silica nanoparticles for sustained drug release
초록 Phosphorylcholine surface modified MCM41 mesoporous silica nanoparticles (MSNs) were prepared by post condensation method. Phosphorylcholine groups were generated by the ring-opening reaction of 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) subsequent to 3-bromopropyl triethoxy silane immobilization. Modified nanoparticles were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, small-angle X-ray scattering (SAXS), SEM, TEM and N2 adsorption-desorption analyses. Phosphorylcholine modified MSNs were found to have well-ordered meso-structural integrity and morphology of MCM41 with some reduction in their pore size and pore volume. The drug molecules were loaded effectively onto phosphorylcholine modified silica nanoparticles. The drug-loaded MSN-PC showed the sustained release of alendronate molecules under physiological pH conditions (pH 7.4).
저자 리야수드힌 네치카투, 박성수, 하창식
소속 부산대
키워드 Mesoporous silica nanoparticles; MCM-41; Phosphorylcholine; Drug release; Adsorption.
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