화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO))
권호 44권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Alginate based injectable hydrogels for protein delivery and bone repairing
초록 Stimuli responsive injectable hydrogel have potentials as bone repairing due to their ability to form three-dimensional networks under mild conditions, to be introduced into body in a minimally invasive manner. Also, alginate is broadly studied because of not only similar property above but also ease of chemical modification with adhesion ligand. Recently, our group proposed temperature sensitive hydrogels as carriers for Bone Morphogenetic Protein 2 (BMP-2). The hybrid polymer Alg-PCLA was comprised of alginate and poly(ε-caprolactone-co-lactide). Alg-PCLA was blended with poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) to form hybrid hydrogel. Alginate is modified with phosphate group which can induce hydroxyapatite and increase mineralization property. Hybrid hydrogel exhibited sustained BMP-2 release and hydroxyapatite was well induced in vitro. Thus, we can expect alginate based injectable hydrogel has great potential for bone repair.
저자 김성한, 이두성
소속 성균관대
키워드 alginate; injectable hydrogel; sustained delivery; BMP-2; bone repairing
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