||Vascular disease have still threaten human life until now. To overcome it, ePTFE vascular grafts have been mainly used in clinics. However, in ePTFE vascular grafts, poor long-term patency and restenosis may occur after bypass surgery and usually lead to implant failure. Thus, surface modification is necessary to overcome the limitations of artificial graft. It could induce graft to remodel like native vessels by recruiting vascular cells. Heparin, which inhibits thrombosis, and substance P, which recruits stem cells and induce the formation of blood vessels, were covalently conjugated with Poly(l-lactide-co-ε-caprolactone) (Hep-PLCL and SP-PLCL). Hep-PLCL and SP-PLCL was vacuum coated onto the surface of ePTFE to induce the regeneration of vascular cells inside of the pore. In vivo test, coating of Hep/SP-PLCL stimulate the regeneration by promoting angiogenesis and recruiting M2 macrophage and MSCs.