화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO))
권호 44권 1호
발표분야 기능성 고분자
제목 Intra-articular injection of corticosteroid encapsulated polymer nanoparticle to inhibit osteoarthritic progress for long-term period
초록 Treatment of the osteoarthritis (OA) by using corticosteroid (CS) is a common method due to their anti-inflammatory effect. But still, they have drawbacks such as fast clearance and potential side-effect. Therefore, we suggest a sustained delivery of CS which is a prolonged and safe way to intra-articular (IA) cartilage for the inhibition of progressive OA. We developed an IA injectable CS encapsulated polymer nanoparticle that needs only a mixing between CS and polymer and then a single IA injection for the long-term treatment of OA. During mixing, our thermosensitive poly(phosphazene) hydrogel embraces CS to its network by hydrophobic interaction and becomes nano-sized particle structure. This enabled the CS to be slowly released out and had a potent inhibitory effect against OA progression without causing significant side-effects. Taken together, this system can be a decent tool as an IA drug delivery depot for treating OA for a long-term in a safe manner.
저자 권영중, 송수창
소속 한국과학기술(연)
키워드 Thermosensitive hydrogel; Corticosteroid; Polymer nanoparticle; Osteoarthritis; Intra-articular injection
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