화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO))
권호 44권 1호
발표분야 고분자합성
제목 DOX/IR780 dye co-loaded polymeric vesicles as dual stimuli-responsive nanocarriers for synergistic chemo/photothermal therapy
초록 Stimuli-responsive polymer nanocarriers mediated drug delivery is one of the most promising platforms for targeting antitumor treatment. In this work, by using a combination of reversible addition fragmentation chain transfer polymerization (RAFT) and ring opening polymerization, we present an efficient approach for preparing a series of disulfide-containing amphiphilic polypeptide hybrids, poly(N-isopropylacrylamide)-block-poly(3,4-dihydroxy-L-phenylalanine) (PNIPAM-b-PDOPA). After the aminolysis of the RAFT end group and the deprotection of acetyl group, the resulting hybrids were able to self-assemble into stabilized and uniform micelles in which doxorubicin and IR780 are efficiently encapsulated. The in vitro cell viability assays results illustrated that the PNIPAM-b-PDOPA hybrid bioconjugates might serve as highly biocompatible and multifunctional nanocarriers for practical applications.
저자 yu zhang1, 김일1, Saji Uthaman2, 박인규2
소속 1부산대, 2전남대
키워드 Chemotherapy; Drug delivery; Photothermal therapy
E-Mail