||Titanate nanotubes are widely used in various fields, but their weak thermal stability limits their application for catalyst supports. Here, we have discovered that titanate nanotubes with thick multi-walled structures can be fabricated by rotation-assisted synthesis. Porous structure of conventional nanotubes fabricated without rotation were easily collapsed after thermal treatment, whereas the nanotubes having a thick multiwalled structure retained their pore structure and the specific surface area (∼300 m2/g) even after calcination at 400°C in air. Vanadium–tungsten-oxide catalysts supported on the multi-walled titanate nanotubes were applied to NH3-selective catalytic reduction, which showed stable NOx reduction performance with high selectivity to N2 even after hydrothermal aging. The activity and stability of the newly prepared catalysts were found to be correlated with sintering of VOx on titanate nanotubes. This study demonstrats that the initial morphology of titanate nanotubes can have a significant effect on the activity of catalysts in long-term SCR operation.