화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2018년 가을 (10/24 ~ 10/26, 대구 EXCO)
권호 24권 2호, p.1851
발표분야 재료(Materials)
제목 Development of post-processed attachment of Antibody into Hydrogel Microparticle for CTC capture
초록 Circulating tumor cell (CTC) detection technology is essential for isolating CTC, which is important biomarker of cancer, from blood by liquid biopsy. Since applying hydrogel microparticles in CTC detection has advantages compared to other approaches in the point of customization, biocompatibility and cell manipulation, we introduce microparticles covered with antibody against epithelial cell adhesion molecule to capture CTC. Improving previously published work which utilizes carboxylic acid groups to alter unconverted double bond in hydrogel microparticle into carboxylic acid groups to alter unconverted double bond in hydrogel microparticle into carboxylic acid groups. Adding more carboxylic acid groups by the application shows more antibody attachment through fluorescence intensity test. Introducing additional carboxylic acid groups by thiol linking increases the number of total available carboxylic acid groups by thiol linking increase the number of total availabe carboxylic acid groups and is expected to improve affinity of the microparticles for CTC detection.
저자 이낙준1, 봉기완1, 황기태2, 맹세정2
소속 1고려대, 2보라매병원
키워드 화공소재 전반
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