화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터)
권호 43권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Antibiotic-Loaded Alginate/Hyaluronic Acid Hydrogel for the Treatment of Acute Osteomyelitis
초록 Osteomyelitis can result from trauma, nosocomial infection, or orthopedic operation. Although the understanding of infectious diseases and the development of surgical/pharmaceutical therapeutic techniques are rapidly growing, osteomyelitis continues to be a challenge for orthopedic surgeons. Local delivery of antibiotics offers several advantages, including fewer side effects and higher local concentration of a given medicine compared to the systemic one. Compared to the other biode-gradable polymers, in situ alginate/hyaluronic acid hydrogel possesses several additional advantages, including easy preparation and free of harmful organic solvents in the formulation process. In this study, we prepared an injectable antibiotic (vancomycin)-loaded alginate/hyaluronic acid hydrogel for osteomyelitis treatment. The in vitro antibiotic release, cytotoxicity, and antibacterial activity of the antibiotic-loaded hydrogel were investigated.
저자 김태호1, 서다래1, 최희주1, 허다빈1, 오세행2, 이진호1
소속 1한남대, 2단국대
키워드 Antibiotic; Alginate; Hyaluronic Acid; Hydrogel; Acute Osteomyelitis
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