화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터)
권호 43권 1호
발표분야 의료용 고분자 부문위원회 I
제목 Dual Crosslink Alginate/Gelatin Hydrogels As Scaffolds for Cartilage Repair
초록 Compared with synthetic scaffold, biopolymeric scaffold has been considered more profitable to regulate adhesion, differentiation and migration of cells. Alginate is biocompatible, nonimmunogenic and rapidly forms a gel by adding multivalent cations. To improve cell-interactive properties of alginate hydrogel, proteins including gelatin are often included. Gelatin is a biopolymer obtained after hydrolysis of collagen which is the major protein of the ECM. Gelatin has low immunogenicity and excellent bioaffinity. In this study, we fabricated alginate/gelatin hydrogel by dual crosslinking in order to retain more gelatin in the hydrogel. To obtain optimum condition of hydrogel, we regulated the ratio of alginate to gelatin methacrylate. Gelatin content in the hydrogel was calculated by measuring the solid content with a moisture analyzer. The structure of hydrogel was investigated by 1H-NMR, FT-IR and SEM. In addition, we evaluated mechanical properties of hydrogel by UTM and rheometer.
저자 김정은, 김정수, 이현지, 이기훈
소속 서울대
키워드 Dual crosslink; alginate; gelatin; hydrogel; scaffold
E-Mail