화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터)
권호 23권 2호, p.1740
발표분야 생물화공
제목 Development of Drug Delivery System for Controlled Release using Novel Structured Silica Nanoparticles
초록 Nanocarriers confer a higher ratio of surface area to volume to improve the pharmacokinetics and biodistribution of therapeutic agents, thus maximize loading efficiency of the therapeutic agents and advanced release profiles. In this study, we developed novel nanocarriers of open porous silica nanoparticles to achieve the purpose of prolonged concentration of therapeutic agents and controlled release. Since our silica nanoparticles have radially oriented mesopores, in which their size gradually increases while proceeding from the center to outer surface of the nanoparticle, they provide large surface area and permit target drugs to easily access the active site of the surface that are located the pores. Thus, the silica nanoparticles are capable of containing a much higher concentration of target drugs than other porous nanoparticles. When dexamethasone and ibuprofen were selected and tested as a therapeutic agent, the loading efficiency into the silica nanoparticles was determined to be ca. 270 %. Furthermore, through surface treatments of the silica nanoparticles, pH and temperature dependent controlled release of the drugs was achieved.
저자 김지나, 홍수린
소속 차의과학대
키워드 생물화공
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