화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터)
권호 42권 2호
발표분야 의료용 고분자 부문위원회 I
제목 Surface modification of mesenchymal stem cells with RGD-peptide for modulating cell stability and functions
초록 Mesenchymal stem cells (MSCs), which is multipotent stromal cells, has been clinically administrated for graft-versus-host disease, sepsis, paralysis and stroke by direct intravenous injection. In order to increase cellular stability during administration, we have prepared multilayer films using RGD peptide on individual MSCs, resulting that film coated MSCs showed significantly increase cell survival during agitation culture which is mimicked blood vessel, having cytoprotective effect of film which could be also supported by the activation of survival-related protein, Akt. The multilayer film does not interfere cell differentiation, attachment and migration, keeping that cellular openness after coating. In addition, the multilayer films showed the increased survival rate in blood circulation and stem cell recruitment at injured area. Therefore, in this study, we concluded that the RGD-peptide film is powerful tool for in vivo transplantation in stem cell therapy.
저자 최다희, 홍진기
소속 중앙대
키워드 Layer-by-layer assembly; Mesenchymal stem cell; RGD-peptide; Cytoprotective effect
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