화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터)
권호 42권 2호
발표분야 기능성 고분자
제목 Simultaneous delivery of various siRNAs and anticancer drug via multiple monocomplexation-induced hydrophobic association for prostate cancer therapy
초록 Prostate cancer is one of the major mortality disease and the research on its treatment has been active. There are several studies using siRNAs that inhibit the activity of the androgen receptor which is specifically present in prostate and helps growing of prostate, but more effective treatments are still required. In this study, we propose to treat prostate cancer more effectively by delivering both several kind of siRNAs and anticancer drug at once. We developed a colloidal formulation (< 10 nm) of the hydrophobically associated multiple monocomplex (HMPlex) which consists of siRNAs, apoptotic-anticancer drug, and Pluronic F-68 to deliver to prostate cancer cells. We have compared various combinations of siRNAs in the HMPlex in vitro and in vivo, and the results showed that simultaneously silencing various genes was more effective in inducing cell apoptosis than silencing a single gene in prostate cancer cells.
저자 유원재1, 최은실2, 박재형1, 김세훈2
소속 1성균관대, 2한국과학기술(연)
키워드 siRNA; prostate cancer; simultaneous delivery
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