화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터)
권호 42권 2호
발표분야 고분자합성
제목 Two Tail Tadpole-shaped Polypeptide
초록 The biocompatible tadpole-shaped polypeptide with one cyclic polypeptide ring and two chain tails were synthesized by N-heterocyclic carbene (NHC)-mediated ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs). First, the NHC precursor, with two chains at the nitrogen was prepared by a simple anion metathesis of imidazole(in)ium chlorides with KHCO3. Then NHC releasing from the [NHC(H)][HCO3] directly initiated the ROP of NCA to produce the cyclic polypeptide. Finally, the tadpole-shaped polypeptide with two regulable tails were obtained. The target polypeptides were characterized by nuclear magnetic resonance spectrum, fourier transform infrared spectroscopy, gel permeation chromatography and matrix-assisted laser desorption ionization-time of flight mass spectra. This pioneering approach simplify the synthesis procedures of tadpole-shaped polypeptide compared to other methods which usually requires specific intramolecular ring-closure reaction.
저자 진화, 김일, 장위, 쑹원량
소속 부산대
키워드 Cyclic polypeptide; α-amino acid N-carboxyanhydrides; N-heterocyclic carbene; Ring-opening polymerization; Tadpole-shaped
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